During pregnancy (especially in I trimester) is used only for health reasons. If long-term treatment during pregnancy does not exclude the possibility of fetal growth. In case of application in the III trimester of pregnancy there is a risk of atrophy of the fetal adrenal cortex, which may necessitate replacement therapy in the newborn. Since steroids penetrate into breast milk, if necessary, use primobolan cycle during breast-feeding, breast-feeding is recommended to stop.
Dosage and administration The dose and duration of treatment is determined by the doctor individually, depending on the indication and the severity of the disease.
. Tablets entire recommended daily dose taken once daily dose or double – through day given endogenous circadian secretion of glucocorticoids in the range from 6 to 8 o’clock. The highest daily dose can be divided into 2-4 reception, with the morning dose should be taken large. Tablets should be taken during or immediately after a meal with a small amount of liquid. In acute conditions, and as replacement therapy in adults prescribed an initial dose of 20-30 mg / day maintenance dose is – 5-10 mg / day. If necessary, the initial dose may be 15-100 mg / day maintenance -5-15 mg / day. For children, the initial dose is 2.1 mg / kg of body weight per day in 4-6 receptions supporting – 300-600 g / kg per day. Chronic administration primobolan cycle of the drug daily dose should be reduced gradually. Duration of therapy should not be stopped abruptly!
The solution for intravenous and intramuscular administration. Prednisolone Nycomed is administered intravenously (bolus or infusion) or intramuscularly. Intravenous drug is usually administered first jet, then drip.
The product is a ready solution. Is prevented from breeding in any of infusion and injection solutions! In acute adrenal insufficiency single dose is 100 – 200 mg, 300-400 mg daily. Severe allergic reactions Nycomed prednisolone administered in a daily dose of 100-200 mg for 3- . 16 days in bronchial asthma drug is administered depending on the severity of the disease and the effectiveness of complex treatment of 75 to 675 mg per course of treatment from 3 to 16 days; in severe cases the dose may be increased to 1400 mg per treatment and a gradual reduction in dose. In asthmatic status Nycomed prednisolone administered at a dose of 500-1200 mg per day, followed by a decrease to 300 mg per day, and the transition to maintenance doses. When tireotoksicheskom Stroke is administered primobolan cycle at 100 mg per daily dose of 200-300 mg; if necessary, the daily dose may be increased up to 1000 mg. The duration of administration depends on the therapeutic effect, typically up to 6 days. In shock, resistant to standard therapy, prednisolone Nycomed at the beginning of therapy is typically administered bolus, followed by moving to a drip. If within 10-20 minutes did not increase blood pressure, repeated bolus formulation. After removal from the state of shock continue to drip to stabilize blood pressure. A single dose of 50-150 mg (in severe cases – up to 400 mg). Re-drug is administered 3-4 hours. The daily dose can be 300-1200 mg (followed by a dose reduction). In acute renal failure (acute poisoning, postoperative and postpartum periods, etc.), Prednisolone Nycomed is administered at 25-75 mg per day; when indicated daily dose may be increased to 300-1500 mg per day and higher. In rheumatoid arthritis and systemic lupus erythematosus Nycomed prednisolone administered in addition to the reception system in drug dose of 75 -125 mg per day, no more than 7-10 days. In acute Nycomed hepatitis prednisolone administered at 75-100 mg per day for 7-10 days. When poisoning cauterizing liquids with burns of the digestive tract and upper respiratory tract Prednisolone Nycomed prescribed in doses of 75-400 mg per day for 3-18 days. If it is impossible intravenous administration of prednisolone Nycomed injected intramuscularly at the same dose. After the relief of acute state appointed interior Nycomed prednisolone tablets, followed by a gradual reduction in dose. Chronic administration of the drug daily dose should be reduced gradually. Duration of therapy should not be stopped abruptly!
Side effects. The frequency and severity of side effects depend on the duration of application, size of the dosage used and the possibility of compliance circadian rhythm destination prednisolone Nycomed.When using prednisolone Nycomed may occur: On the part of the endocrine system: reduction of glucose tolerance, steroid diabetes or a manifestation of latent diabetes mellitus, adrenal suppression, Cushing’s syndrome (moon face, obesity, pituitary type, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, muscle weakness, striae) delayed sexual development in children. from the digestive system: nausea, vomiting, pancreatitis, steroid stomach ulcers and duodenal ulcers, erosive esophagitis, primobolan cycle gastrointestinal bleeding and perforation of the wall of the gastrointestinal tract, increased or decreased of appetite, indigestion, flatulence, hiccups. In rare cases – increased activity of “liver” transaminases and alkaline phosphatase.
Cardio-vascular system: arrhythmia, bradycardia (up to cardiac arrest); development (in predisposed patients) or increased severity of heart failure, electrocardiographic changes typical of hypokalemia, increased blood pressure, hypercoagulation, thrombosis. In patients with acute and subacute myocardial infarction – the spread necrosis, slowing the formation of scar tissue, which can lead to rupture of the heart muscle. From the nervous system: delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, increased intracranial pressure, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor cerebellum, headache, convulsions. from the sensory organs: posterior subcapsular cataracts, increased intraocular pressure with possible damage to the optic nerve, the propensity to develop secondary bacterial, fungal or viral eye infections trophic changes of the cornea, exophthalmos, sudden loss of vision (for parenteral administration in the area of the head, neck, nasal turbinate, the scalp may be the deposition of crystals of the drug in the blood vessels of the eye). On the part of metabolism: increased excretion of calcium, hypocalcemia, increased body weight, negative nitrogen balance (increased protein breakdown), increased sweating. Conditional mineralocorticoid activity – delay of fluid and sodium (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue). From the musculoskeletal system: slowing growth and the processes of ossification in children (premature closure of epiphyseal growth zones), osteoporosis (very rare – pathological fractures, aseptic necrosis of the humeral head and femur), rupture of tendons of muscles, steroid myopathy, reduced muscle mass (atrophy). from the skin and mucous membranes: delayed wound healing, petechiae, ecchymosis, thinning of the skin, hyper- or hypopigmentation, steroid acne, striae, susceptibility to the development of pyoderma and candidiasis. allergic reactions: skin rash, pruritus, anaphylactic shock, local allergic reactions. local at parenteral administration: a burning sensation, numbness, pain, tingling at the site of injection, infection at the injection site, rarely – necrosis of surrounding tissue, scarring at the injection site; atrophy of the skin and subcutaneous tissue with the / m introduction (especially primobolan cycle dangerous administration in the deltoid muscle). Other: development or exacerbation of infection (the appearance of this side effect contribute jointly used immunosuppressants and vaccination), leucocyturia syndrome “cancel” at / in the introduction – “tides” of blood to the face.
Overdose may be increased side effects described above. It is necessary to reduce the dose of prednisolone Nycomed. Treatment – symptomatic.
Interaction with other drugs is possible prednisolone pharmaceutical incompatibility with other intravenously administered drugs – it is recommended to be administered separately from other drugs (in / bolus or through an IV, etc., as the second solution.). When mixed with a solution of prednisolone heparin precipitate formed. steroid purchase online oxydine buy steroids online