On the part of the endocrine system : reduction of glucose tolerance, steroid diabetes or a manifestation of latent diabetes mellitus, depression adrenal glands, primobolan dosage syndrome (moon face, obesity, pituitary type, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, muscle weakness, striae) delayed sexual development in children. from the digestive system : nausea, vomiting, pancreatitis, steroid ulcers gastric and duodenal ulcers, erosive esophagitis, gastrointestinal bleeding and perforation of the wall of the gastrointestinal tract, increased or decreased appetite, indigestion, flatulence, hiccups.
In rare cases, -increasing activity of “liver” transaminases and alkaline phosphatase. Cardio-vascular system: arrhythmia, bradycardia (up to cardiac arrest); development (in predisposed patients) or increased severity of heart failure, electrocardiographic changes typical of hypokalemia, increased blood pressure, hypercoagulation, thrombosis. In patients with acute and subacute myocardial infarction – the spread necrosis, slowing the formation of scar tissue, which can lead to rupture of the heart muscle.
From the nervous system : delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, increased intracranial pressure, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor cerebellum, headache, convulsions. from the sensory organs : posterior subcapsular cataracts, increased intraocular pressure with possible damage to the optic nerve, the propensity to develop secondary bacterial, fungal or viral eye infections trophic changes of the cornea, exophthalmos, sudden loss of vision (for parenteral administration in the area of the head, neck, primobolan dosage nasal turbinate, the scalp may be the deposition of crystals of the drug in the blood vessels of the eye), the part of metabolism : increased excretion of calcium, hypocalcemia, increased body weight, negative nitrogen balance (increased protein breakdown), increased sweating. Conditional mineralocorticoid activity – fluid retention and sodium (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue). From the musculoskeletal system: slowing growth and ossification processes in children (premature closure of epiphyseal growth zones), osteoporosis (very rare -patologicheskie fractures, aseptic necrosis of the humeral head and femur), rupture of tendons of muscles, steroid myopathy, reduced muscle mass (atrophy). for the skin and mucous membranes : delayed wound healing, petechiae, ecchymosis, thinning of the skin, hyper- or hypopigmentation, steroid acne, striae, susceptibility to the development of pyoderma and candidiasis. Allergic reactions : skin rash, pruritus, anaphylactic shock local allergic reactions.local when administered parenterally : burning, numbness, pain, tingling in the introduction, infection at the injection site, rarely – necrosis of surrounding tissue, scarring at the injection site; atrophy of the skin and subcutaneous tissue with the / m introduction (especially dangerous administration in the deltoid muscle). Other : development or exacerbation of infection (the appearance of this side effect contribute jointly used immunosuppressants and vaccination), leucocyturia, “cancellation” syndrome.
may be increased side effects described above. It is necessary to reduce the dose Prednizola. Treatment – symptomatic.
Interaction with other drugs
is possible Prednizola pharmaceutical incompatibility with other intravenously administered drugs – it is recommended to be administered separately from other drugs (in / bolus or through an IV, etc., as the second solution.). When mixed with heparin solution Prednizola precipitate formed.
Simultaneous with the appointment Prednizola with : inducers primobolan dosage of “liver” mikrosomalnyh enzymes (phenobarbital, rifampin, phenytoin, theophylline, ephedrine) leads to a decrease in its concentration;diuretics (especially “thiazide” and inhibitors of carbonic anhydrase ) and amphotericin B – may lead to increased excretion of K +, and increased risk of heart failure, with a sodium-containing drugs – to the development of edema and high blood pressure, cardiac glycosides – worsening their tolerance and increases the likelihood of ventricular ekstrasitolii (due to induced hypokalemia), indirect anticoagulants – weakens (rarely strengthens) their action (required dose adjustment); anticoagulants and thrombolytics – increases the risk of bleeding from ulcers in the gastrointestinal tract, ethanol, and nonsteroidal anti-inflammatory drugs (NSAIDs) -usilivaetsya risk of erosive and ulcerative lesions of the gastrointestinal tract and of bleeding (in combination with NSAIDs in the treatment of arthritis may reduce the dose of corticosteroids due to the summation of therapeutic effect); paracetamol – increases the risk of hepatotoxicity (induction of hepatic enzymes and the formation of toxic metabolites of paracetamol),acetylsalicylic acid – accelerates its excretion and reduces the concentration in the blood (with the abolition Prednizola level of salicylates in the blood increases, and increases the risk of side effects), insulin and peroralnymi hypoglycemic agents, antihypertensive agents – decreases their effectiveness; vitamin the D – reduces its impact on the absorption of Ca2 + in the intestine; growth hormone – decreases the effectiveness of the latter, and with praziquantel – its concentration; M holinoblokatorami (including antihistamines and tricyclic antidepressants) and nitrate – contributes to the intraocular pressure isoniazid and mexiletine – increases their metabolism (especially for “fast acetylators”), which primobolan dosage leads to a decrease in their plasma concentrations. Carbonic anhydrase inhibitors and “loop” diuretics may increase the risk of osteoporosis. Indomethacin, displacing Prednizol from its association with albumin, increases the risk of its side effects.