Co-administration of prednisone with: inducers of “liver” microsomal enzymes (phenobarbital, rifampin, phenytoin, theophylline, rifampicin, ephedrine) leads to a decrease in its concentration; diuretics (especially “thiazide” and carbonic anhydrase inhibitors) and amphotericin B – may lead to increased excretion of potassium the body and increase the risk of developing heart failure, carbonic anhydrase inhibitors, and “loop” diuretics may increase the risk of osteoporosis, a sodium-containing primobolan enanthate drugs – to the development of edema and high blood pressure, cardiac glycosides – worsening their tolerance and increases the likelihood of ventricular ekstrasitolii (due to induced hypokalemia), indirect anticoagulants – weakens (strengthens less) of their action (required dose adjustment); anticoagulants and thrombolytics – increases the risk of bleeding from ulcers in the gastrointestinal tract, ethanol, and nonsteroidal anti-inflammatory drugs – enhanced risk erozivno- ulcers in the gastrointestinal tract and of bleeding (in combination with for the treatment of arthritis may be reduced dose glucocorticosteroids for summation therapeutic effect); indomethacin – increased risk of side effects of prednisolone (displacement indomethacin prednisolone in connection with albumin) paracetamol – increases the risk of hepatotoxicity (induction of hepatic enzymes and the formation of toxic metabolites of paracetamol), acetylsalicylic acid – accelerates its excretion and reduces the concentration in the blood (with the abolition of prednisolone salicylate level primobolan side effects in the blood increases, and increases the risk of side effects), insulin and peroralnymi hypoglycemic agents, antihypertensive agents – decreases their effectiveness; vitamin the D – reduces its impact on the absorption of Ca 2+ in the intestine; growth hormone – decreases the effectiveness of the latter, and with praziquantel – its concentration;
M holinoblokatorami (including antihistamines and tricyclic antidepressants), and nitrates – improves intraocular pressure;isoniazid and mexiletine . – increases their metabolism (especially in the “slow” acetylators), which leads to a decrease in their plasma concentrations of increases the effects of prednisolone.ergocalciferol and parathyroid hormone hinder the development of osteopathy, called prednisone. cyclosporin and ketoconazole , slowing down the metabolism of prednisolone, can in some cases increase its toxicity. Concurrent administration of androgen and steroid anabolic drugs with prednisone promotes the development of peripheral edema and hirsutism, acne. Estrogens and oral estrogensoderzhaschie contraceptives decrease prednisone clearance, which may be accompanied by increased expression of his actions. Mitotane and other inhibitors of the cortex function primobolan cycle adrenal glands may necessitate increasing the dose of prednisone. while the use of railway ivymi antiviral vaccines and compared to other types of immunization increases the risk of activation of viruses and the development of infections.Immunosuppressive drugs increase the risk of infections and lymphoma or other lymphoproliferative disorders associated with Epstein-Barr virus. Antipsychotic agents (neuroleptics) and azathioprineincreases the risk of developing cataracts in the appointment of prednisolone. Co-administration of antacids reduces absorption of prednisolone. while the use primobolan enanthate of antithyroid drugs is reduced, and since thyroid hormones – increases the clearance of prednisolone.
Special instructions. During treatment with prednisolone Nycomed (especially long) must be monitored ophthalmologist, blood pressure control, the state of water and electrolyte balance, as well as patterns of peripheral blood and the blood glucose level. In order to reduce the side effects can be given antacids, and increase potassium intake the body (diet, potassium supplements). Food should be rich in proteins, vitamins, with the restriction of fat, carbohydrates and salt. The drug is enhanced in patients with hypothyroidism and liver cirrhosis. The drug may exacerbate existing emotional instability or psychotic disorders. When referring to psychosis in history Prednisolone Nycomed in high doses administered under strict medical supervision. Caution should be used in acute and subacute myocardial infarction – may spread necrosis, slowing the formation of scar tissue and rupture of the heart muscle. In stressful situations during maintenance treatment ( eg, surgery, trauma, or infectious diseases) should be carried out correction dose due to the increased need for glucocorticosteroids. It is necessary to carefully monitor patients for a year after the end of long-term therapy with prednisolone Nycomed in connection with the possible development of relative adrenal insufficiency in stressful situations. With the sudden cancellation, particularly in the case of the prior use of high doses primobolan acetate may develop the syndrome of “cancellation” (anorexia, nausea, lethargy, generalized musculoskeletal pain, general weakness), as well as exacerbation of the disease, about which he was appointed Prednisolone Nycomed. During prednisolone Nycomed should not be vaccinated due to the reduction of its effectiveness (immune response). prednisolone Nycomed during intercurrent infections, septic conditions, and tuberculosis, treatment with antibiotics is necessary to simultaneously bactericidal action. The children during long-term treatment with prednisolone Nycomed should be carefully monitored for the growth and development dynamics. Children who during the treatment period were in contact with patients with measles or chickenpox, prophylaxis prescribe specific immunoglobulins. Due to the weak mineralocorticoid effect for replacement therapy in adrenal insufficiency Prednisolone Nycomed is used in combination with a mineralocorticoid. Patients content of blood glucose should be controlled diabetes and the need to correct therapy. Showed radiological control of bone and joint system (spine images, brushes). Primobolan enanthatein patients with latent infectious diseases of kidneys and the urinary tract can cause pyuria, which may be of diagnostic value. Prednisolone Nycomed increases the content of 11- and 17 metabolites -oksiketokortikosteroidov.