Trimetazidine exerts anti-hypoxic action. Directly affecting the cardiomyocytes and neurons in the brain and optimize their metabolism and function. Cytoprotective effect is due to an increase in energy potential, activation of oxidative decarboxylation and rationalization of consumption of oxygen (increased aerobic glycolysis and fatty acid oxidation blockade). Supports myocardial primobolan for sale contractility, prevents a decrease in intracellular adenosine triphosphate ( ATP) and phosphocreatine. The conditions of acidosis normalizes the functioning of membrane ion channels, prevents the accumulation of calcium and sodium ions in cardiomyocytes, normalizes intracellular concentration of potassium ions. Reduces intracellular acidosis and elevated phosphate levels caused by myocardial ischemia and reperfusion. Prevents the damaging action of free radicals, preserves the integrity of cellular membranes prevent neutrophil activation in the ischemic area, increases the electric potential decreases the yield of creatine kinase from the cells and the severity of ischemic myocardial injury. Angina reducing the frequency of attacks and the need for the application of nitroglycerine, after 2 weeks of treatment is increased exercise tolerance, improve the contractile function of the left ventricle in patients with coronary dysfunction, reduced blood pressure drops (BP). Reduces dizziness and tinnitus. In vascular pathology eyes improves the functional activity of the retina eyes.
Following oral administration of trimetazidine is rapidly and almost completely absorbed in the gastrointestinal tract, bioavailability – 90%. Time to reach maximum plasma concentration is approximately 5 hours. After 24 hours the concentration in the blood plasma remains at levels above 75% concentration, determined by 11 hours. The equilibrium state is achieved after 60 hours. Food intake does not affect the pharmacokinetic properties of trimetazidine. The apparent volume of distribution of 4.8 (l / kg-1), which explains the good diffusion in the tissues (contact with blood plasma proteins – low, about 16%); easily penetrates the blood-tissue barriers. Trimetazidine primobolan dosage is excreted mainly by the kidneys (60% – unchanged). The half-life in healthy volunteers is approximately 7 hours in patients older than 65 years – about 12 hours. Renal clearance of trimetazidine is directly correlated with creatinine clearance (CC), hepatic clearance decreases with age. The increase in half-life of trimetazidine in elderly patients has no clinical significance.
Indications for use Ischemic heart disease: prevention of angina attacks (in the complex therapy) cochle-vestibular disorders ischemic nature (dizziness, tinnitus, hearing loss).
- Hypersensitivity to any component of the drug;
- renal failure (creatinine clearance less than 15 mL / min);
- expressed human liver;
- age of 18 years primobolan for sale (effectiveness and safety have been established);
- pregnancy, lactation.
Pregnancy and lactation Pregnancy Data on the safety of the drug in pregnancy, and therefore, should abandon the use of the drug during pregnancy. Lactation Data on excretion into breast milk trimetazidine absent. If necessary, use during lactation should stop breastfeeding.
Dosage and administration . Inside, 1 tablet of 35 mg 2 times a day, morning and evening during meals Duration – on doctor’s advice.
Digestive system Common: abdominal pain, diarrhea, dyspepsia, nausea, vomiting. General disorders Common: fatigue. On the part of the central nervous system Common: dizziness, headache. Very rare: extrapyramidal disorders (tremor, rigidity, akinesia), reversible after the abolition of the drug. For the skin and subcutaneous tissue Common: skin rash , pruritus, urticaria. cardio-vascular system rare: orthostatic hypotension, “tides” of blood to the skin.
Overdose There is only limited information on trimetazidine overdose, symptomatic treatment should be carried out in case of an overdose.
Interaction with other medicinal products No information.
Cautions Do not use the drug primobolan for sale for the relief of angina attacks! The drug is not indicated for the initial course of therapy of unstable angina or myocardial infarction. In the case of angina attack should review and adapt therapy.
Effects on ability to drive and other machines The use of the drug does not affect the ability to manage and execute road works that require a high rate of psychomotor reactions. steroidit netista bodybuilder arnold buy tramadol dnp bodybuilding