In the treatment of obsessive-compulsive disorder drug effect appears after 2-4 weeks of treatment; with a further extension of the treatment further improvement primobolan side effects can be observed.
Side effect On the part of the nervous system: rarely – fatigue, tiredness, sleepiness or insomnia, anxiety, tremor, agitation, amnesia, apathy, extrapyramidal effects, mood changes, aggressive behavior, hallucinations, depersonalization, emotional lability, euphoria, mania, hypomania, panic behavior, paranoid reaction, psychosis, serotonin syndrome (agitation, confusion, diarrhea, hyperthermia, hyperreflexia, ataxia, unusual fatigue, tremor, sweating, agitation, uncontrolled behavior).
From the digestive system: rarely – dry mouth, nausea, vomiting, hypersalivation, bloating, diarrhea, abdominal pain, anorexia.
Since the cardiovascular system: rarely – bradycardia, decreased blood pressure, orthostatic hypotension, arrhythmia.
From the side of hematopoiesis: rarely – thrombocytopenia, bleeding.
From the sensory organs: rarely – mydriasis, accommodation paresis, taste disturbance.
From the reproductive system: sexual dysfunction (abnormal ejaculation, decreased libido, impotence), menstrual irregularities.
Allergic reactions: skin rash, rarely – toxic epidermal necrolysis, rhinitis, sinusitis.
Other: rarely – hyperthermia, polyuria, mammalgia, galactorrhea, hyponatremia, violation of urination, arthralgia, myalgia, yawning, gnashing of teeth, increase or decrease in body weight.
In case of overdose may cause the following signs and symptoms: nausea, dizziness, drowsiness, dysarthria, sinus tachycardia, nodal rhythm, sweating, cyanosis, tremor, amnesia, confusion, disturbance of heart rhythm and conduction (prolongation of QT interval), rhabdomyolysis, convulsions, coma.
Treatment: gastric lavage, symptomatic and primobolan side effects supportive therapy; there is no specific antidote.
Interaction with other drugs
Enhances the effect of sumatriptan and other serotonergic drugs.
Does not affect the action of ethanol, drugs Li +, benzodiazepines, antipsychotics (neuroleptics), narcotic analgesics, beta-blockers, phenothiazines, tricyclic antidepressants, antihistamines and medications gipotenzivyh.
To a small extent inhibits cytochrome CYP2D6, in connection with which interacts weakly with drugs that are metabolized by citalopram.
When concomitantly with MAO inhibitors may develop a hypertensive crisis (serotonin syndrome).
Cimetidine increases in blood concentration and enhances the effect of citalopram. When concomitant administration with warfarin the prothrombin time increases by 5%.
drug should be discontinued With the development of mania.
Patients with drug dependence (including history), it is required to monitor and supervise the use of the drug.
Treatment of MAO inhibitors can be started no earlier than 7 days after discontinuation of citalopram.
In elderly patients require dose reduction of citalopram.
Citalopram is not usually suppresses psychomotor reactions. Nevertheless, it is advisable to inform patients taking psychotropic medications that their ability primobolan side effects of concentration of attention may be compromised as a result of their illness or medications taken action, or by a combination of these two factors.